Monobenzone and Vitiligo

 

Vitiligo

Monobenzone and Vitiligo

Monobenzone

Chemistry

Monobenzone is a Dipigmentation agent which is used to treat vitiligo in patient. As it Monobenzyl ether of Hydroquinone it is white crystalline powder and Monobenzone tasteless powder, Physically Monobenzone is soluble in alcohol but not in water, Topical if we use monobenzone on skin it decreases the melanin in skin by removing melanocytes, The whole process is called depigmentation as it makes the whole skin white.

Vitiligo

Vitiligo Can be treated by two way:

1 Depigmentation(Monobenzone, Hydroquinone, Azelaic Acid) 2 Repigmentation (Trioxsalen Topical sodium)

Monobenzone is real depigmentation agent And is effective in vitiligo treatment. and reducing melanin by reducing melanocytes metabolism. But rest of three lightner are not permanent skin lightner. But Result of Monobenzone is permanent and perfect. So Monobenzone is Perfect Skin lightener.

Vitiligo Can be treated by two ways:

1 Depigmentation(Monobenzone, Hydroquinone, Azelaic Acid)

2 Repigmentation (Trioxsalen Topical sodium)

Monobenzone is used for dipigmentation but is being sold by some fake websites. We are the only company have proved that we are selling pure and real Monobenzone under the brand name Benoquin. But this products is manufactured to treat Vitiligo and now people are using it for Skin lightening or skin whitening, with improper knowledge of the drug. Monobenzone can be used for skin lightning but you should have proper knowledge of drug and consult doctor how to use it. One thing matters more is, Whether it is pure. Actually what happened people start using it without any consultation and study. Directly buy it and Do not check that is it real Monobenzone and start using it. When you use real Monobenzone on skin then you will see results of lightness And also Monobenzone Cream is very irritating

To Verify Purity of our Monobenzone Cream, You can test it from any Laboratory, It will not contain 1% Less or 1% More Monobenzone in cream and will be Only Pure Monobenzone 20% Cream.

People have not vitiligo Use Monobenzone(Benoquin) for:

1.Depigmentation

2. Skin Lightening

As per experience it is found that Concentration Over than Monobenzone 20% result in white patches or Vitiligo. When one apply this drug un-uniformly, the part on which application of drug is extra will become extra white and where application is less, that part will remain darks. So that it start seeming that drug is giving white patch. Not drug our extra usage in giving white patches. After-all every thing has some advantage and disadvantages. Just watch what are disadvantages and how they are coming. Like one apply cream 20 % on skin it is very irritating, Then decrease dose and watch skin daily in mirror and try to find good or bad results on skin, if you find that some part of skin is going extra white stop using on that part, Is it not simple, If You don’t watch your skin to whom you want to make white then how you imagine that you will get result. Don’t use Monobenzone as a machine, Based on result decrease concentration or even stop using on that part those getting extra lightness and parallely consult your doctor.

How to use Monobenzonecream 20%(Benoquin)?

First take out whole cream from five packs of tubes and put them in mixer and in same mixer put Olive Oil or Almond oil 678 ml and now mix both them and as it will not proper dissolved in oil, now you can see some grain of cream in oil. Put this mixture into jar and now it is ready.On wet body use the mixture on 2 times a day. Be sure that you have to watch body part daily to whom you want to make light.

Like you feel the some part is dark than other part then in oil there is white grain of cream. Use that grain on that part but in small quantity. Use as much small quantity as you can and watch result daily and decrease or Increase usage on behalf of results.

 

Monobenzone

Introduction: Monobenzone is a derivative of hydroquinone which is potent demelanizing agent destroys melanocytes and many cause permanent depigmentation. Full effect takes 4-6 months and treated areas shoud be protected from sunlight by a sunscreen. Its bleaching action is somewhat irregular which results in ugly pigmented patches. Monobenzone 20% cream should be used 2-3 times daily. USES: Monobenzone is used to treat the loss of skin color (vitiligo). Monobenzone works by permanently removing color from normal skin located around skin with vitiligo. Do not use Monobenzone for other skin color conditions (e.g., freckling, age spots, etc.).

HOW TO USE: Monobenzone is for use on the skin only. Apply a thin layer of the monobenzone cream two or three times daily to colored skin; or use as directed by your doctor. After using this medication, the skin will be permanently affected and sensitive to sunlight. Avoid prolonged exposure to sunlight, wear protective clothing, or use sunscreens regularly when outdoors. It may take up to four months before the full benefit of this drug takes effect. Once the desired skin color is achieved, this medication is applied only as needed to maintain your new skin color (usually two times a week).

SIDE EFFECTS: Dry skin, burning, irritation, redness, cracking or peeling of the skin may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: rash, swelling, skin discoloration of areas not treated with this medication. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: This medication is not recommended for use if you have the following medical conditions: freckles, increased skin color due to perfumes (berlock dermatitis), melasma of pregnancy, inflammation, skin, age spots or "liver spots". Tell your doctor your medical history, especially of: other skin conditions, allergies. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use, especially of: other skin products. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. This medicine may be harmful if swallowed.

MISSED DOSE: If you miss a dose of monobenzone then dont use monobenzone when it comes in mind. If it is near the time of the next dose of monobenzone cream, skip the missed dose of monobenzone creamand resume your usual dosing schedule of monobenzone cream. Do not double the dose to catch up.

STORAGE: Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from light and heat.

Hydroquinone:

Introduction:

Monobenzone is a weak hypopigmenting agent. Monobenzone inhibits tyrosinase and other melanin forming enzymes, decrease formation of and increases degradation of melanosomes. Regular application of monobenzone cream for months is required in melasma, chloasma of pregnancy, etc. The response is required in melasma, chloasma of pregnancy, etc. The response with monbenzone cream is often incomplete and pigmentation may recur when monobenzone cream is discontinued, especially if exposed to sunlight, surscreem are frequently combined. Skin irritation, rashes and allergy are possible. Care to be taken avoid its entry to skin.

Hydroquinone is a skin-bleaching agent that is used to lighten areas of darkened skin such as freckles, chloasma (also known as melasma),age spots, and acne scars.

Hydroquinone is available as a 2% cream for topical application. Hydroquinone can be purchased from a pharmacy. The trade name in New Zealand is Eldoquin®. Some doctors' offices may sell other brands with concentrations up to 4%.

How does hydroquinone work?

Hydroquinone works by decreasing the production and increasing the breakdown of melanosomes (melanin pigment granules) in the skin's pigment cells (melanocytes). It does this by inhibiting the activity of tyrosinase, the enzyme needed to make melanin.

How effective is hydroquinone? In most cases, lightening of skin should be seen after 4 weeks of treatment. Sometimes it may take longer to see any change but if no bleaching effect is seen after 3 months of treatment, you should stop using hydroquinone. To increase the effectiveness of hydroquinone you should stay out of the sun, or wear proctective clothing and use a SPF15+ sunscreen when outdoors. Do not use sunlamps or tanning salons. It is important to use hydroquinone regularly as directed until you achieve the desired bleaching, after which use only as needed to maintain results.

How to use hydroquinone Test for skin sensitivity before using by applying the cream to a small patch of hyperpigmented skin. If no redness or itching occurs within 24 hours, begin treatment.

Clean and dry the skin before applying a thin film of cream twice daily to the area(s) in need of bleaching. Rub into the skin well.

Apply just enough to cover the affected areas and avoid applying to normal skin, as this will lighten as well. Hence wash your hands after applying unless these are areas of treatment. Do not apply near the eyes, mouth, and other mucous membranes. Avoid using other medicated topical products (particularly peroxide products) on the same area at the same time unless directed to do so by your doctor. When using non-medicated cosmetics, sunscreens, and moisturising lotions, apply hydroquinone first, then wait several minutes before applying them over the top.

Side Effects Hydroquinone cream is very well tolerated. Some women may experience minor and temporary skin irritations including mild itching or stinging and reddening of the skin (irritant contact dermatitis). If these do not subside stop using the cream. Side effects that should warrant stopping the cream and seeking medical advice immediately include severe burning, itching, crusting, or swelling of treated areas (possible allergic contact dermatitis) and any unusual skin discolouration. Prolonged use of hydroquinone has been associated with the development of exogenous ochronosis (a persistent blue-black pigmentation), especially in Africa, but this is rare. It might be due to other ingredients such as phenol, resorcinol and antimalarial agents, which are known to cause ochronosis.

Precautions Do not use benzoyl peroxide, hydrogen peroxide, or other peroxide products when using hydroquinone. A temporary dark staining of the skin may occur. If accidentally used together, wash the skin with soap and water to remove the staining. Hydroquinone creams may contain sodium metabisulphite that may cause serious allergic reactions (including anaphylaxis) in certain susceptible people.

Hydroquinone should not be used in pregnancy or when breastfeeding.

Azelaic Acid.

It is drug for hyperpigmentary disorders including melasma. It appear to act by inhibiting the melanin forming enzymes tyrosinase, However, it is a weak demelanizing agent with reversible hypopigmentary action.

USES: This medication is used in the treatment of mild to moderate acne.

HOW TO USE: This is applied to the skin as directed usually twice a day. To apply, clean and pat dry the affected area. Apply a thin layer on the skin and massage in gently. Wash hands well after use. Do not use large amounts or apply this more often than directed. Your condition will not clear faster, but the chance for side effects may be increased. Use for full course of treatment. Avoid contact in or near the eyes or inside the nose and mouth. If it gets in your eyes wash out immediately with plenty of water and call your doctor if irritation persists. Do not apply any type of dressing or covering over the cream unless told to do so by your doctor.

SIDE EFFECTS: Slight stinging or burning, itching, tingling, redness or drying of the skin may occur. If these symptoms continue or become severe or if you develop a skin rash, changes in skin color or a worsening of asthma symptoms, notify your doctor. The cream may cause irritation that may be controlled by using once daily instead of twice daily. Consult your physician. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Before using this, tell your doctor if you have: other illnesses, any allergies. This medication may be used with caution during pregnancy or while breast-feeding. Discuss the risks and benefits with your doctor.

DRUG INTERACTIONS: Tell your doctor or pharmacist of any nonprescription or prescription medication you may use, especially of: other skin products. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. This medicine may be harmful if swallowed.

NOTES: Improvement is usually seen within four weeks. However, it may take several weeks of continued use before the full effects of this medication are evident. Dark-skinned individuals may notice a lightening in skin color. Consult your doctor or pharmacist for advice and report these changes if they occur.

MISSED DOSE: If you miss a dose, apply it as soon as remembered and resume your regular dosing schedule. Do not "double-up" the dose to catch up.

STORAGE: Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C). Do not freeze. Check the expiration date on the tube and discard any expired medication.